Calculate Sensitivities

Determine which model components are sensitive to specific conditions or drugs

Functions

sbiosobolPerform global sensitivity analysis by computing first- and total-order Sobol indices (requires Statistics and Machine Learning Toolbox)
sbiompgsaPerform multiparametric global sensitivity analysis (requires Statistics and Machine Learning Toolbox)
sbiosimulateSimulate SimBiology model
sbioacceleratePrepare model object for accelerated simulations
createSimFunctionCreate SimFunction object
sbiosampleparametersGenerate parameters by sampling covariate model (requires Statistics and Machine Learning Toolbox software)
sbiosampleerrorSample error based on error model and add noise to simulation data
addconfigsetCreate configuration set object and add to model object
getconfigsetGet configuration set object from model object
getsensmatrix (SimData)Get 3-D sensitivity matrix from SimData object

Classes

SimBiology.gsa.SobolObject containing first- and total-order Sobol indices
SimBiology.gsa.MPGSAObject containing multiparametric global sensitivity analysis (MPGSA) results
SensitivityAnalysisOptionsSpecify sensitivity analysis options
SimDataSimulation data
ConfigsetSolver settings information for model simulation
SolverOptionsSpecify model solver options
RuntimeOptionsOptions for logged species
CompileOptionsDimensional analysis and unit conversion options
SimFunctionFunction-like interface to execute SimBiology models
SimFunctionSensitivitySimFunctionSensitivity object, subclass of SimFunction object
ScenariosSimulation scenarios

Apps

SimBiology Model BuilderBuild QSP, PK/PD, and mechanistic systems biology models interactively
SimBiology Model AnalyzerAnalyze QSP, PK/PD, and mechanistic systems biology models

Examples and How To

App Workflow

Find Important Parameters with Sensitivity Analysis Using SimBiology Model Analyzer App

Perform sensitivity analysis to find important model parameters.

Programmatic Workflow

Calculate Sensitivities Using sbiosimulate

This example uses the model described in Model of the Yeast Heterotrimeric G Protein Cycle to illustrate SimBiology® sensitivity analysis options.

Concepts

Sensitivity Analysis in SimBiology

Sensitivity analysis lets you explore the effects of variations in model quantities (species, compartments, and parameters) on a model response.

Model Simulation

Simulate dynamic models using various solvers.

Accelerating Model Simulations and Analyses

Accelerate the simulation or analysis by converting the model to compiled C code.