Can I define two default font sizes using set()

I use a startup script to set my default figure font size to 18 point using the following command.

set(groot,'DefaultAxesFontSize',18);

I default the figure style to 'docked' so this size works well for me. My issue is that this also changes the font size in live scripts.

When using live scripts with 18p figure font the axis area ends up quite small. I would perfer to use 10p font for live script figures. Setting the 'DefaultAxisFontSize' to 10 allows for small defualt font, however I would like to have two setting.

Is it posible to define two defaults, one for live scripts and one for other figures? Thanks