Cleve Moler has written about the Rubik's Cube on a number of occasions in his blog. See a list of search results for Rubik.
If you're trying to solve this as part of a homework assignment, show us the code you've written to try to solve the problem and ask a specific question about where you're having difficulty and we may be able to provide some guidance.
If you aren't sure where to start because you're not familiar with how to write MATLAB code, I suggest you start with the free MATLAB Onramp tutorial to quickly learn the essentials of MATLAB.
If you aren't sure where to start because you're not familiar with the mathematics you'll need to solve the problem, I recommend asking your professor and/or teaching assistant for help.
