How to simulate multiple doses and generate only one plot?

I want to try many dosages of one species and generate only one plot. So I wonder if simbiology has such a function or if I need to use another Matlab tool.

the plot is like this:

Answer 1

[Bhargavi Srija Ramisetty]

Hi Lo,

I believe you can use repeat dosing feature in simbiology.

Best

Srija

Answer 2

[Sam Chak]

Hi @Lo

Are you looking to plot something like this?

m1 = sbiomodel('onecomp');

r1 = addreaction(m1,'drug -> null');
k1 = addkineticlaw(r1,'MassAction');
p1 = addparameter(k1,'ke','Value',1.0,'ValueUnits','1/hour');
k1.ParameterVariableNames = 'ke';

r2 = addreaction(m1,'dose -> drug');
k2 = addkineticlaw(r2,'MassAction');
p2 = addparameter(k2,'ka','Value',0.1,'ValueUnits','1/hour');
k2.ParameterVariableNames = 'ka';

amt = [250 500];    % dosage amount

for j = 1:numel(amt)
    d1 = sbiodose('d1','repeat');
    d1.Amount      = amt(j);
    d1.AmountUnits = 'milligram';
    d1.Interval    = 8;
    d1.TimeUnits   = 'hour';
    d1.RepeatCount = 5;
    d1.Active      = true;
    d1.TargetName  = 'dose';
    
    cs             = getconfigset(m1);
    cs.StopTime    = 48;
    cs.TimeUnits   = 'hour';
    
    cs.RuntimeOptions.StatesToLog = {'drug'};   % comment out this line if want to plot dosage
    [t, sd, species] = sbiosimulate(m1,d1);
    
    plot(t, sd), hold on
end

hold off, grid on
legend('250 mg', '500 mg', 'Location', 'NW');
xlabel('Hours');
ylabel('Drug Concentration');

[Lo]

hi Sam Chak

I'm not very familiar with program. could you please show me in diagram form ? thank you !

best

Eric

[Sam Chak]

Hi @Lo,

I believe you might be referring to the SimBiology Model Analyzer app, which offers a user-friendly graphical interface for entering data and performing actions with just a few clicks. You can find useful information and examples on this page:

https://www.mathworks.com/help/simbio/simbiology-apps.html

Answer 3

[Jeremy Huard]

Hi @Lo,

you can also scan over single dosing parameters such as its amount or even scan over a list of dose objects.

There is an example in the documentation of a scan over a dosing amount that will help you:

https://www.mathworks.com/help/simbio/ug/parameter-scan-to-explore-dosing-regimens.html#mw_752d08c3-6c1b-484b-b1f6-5a28dc7c0e5e

Best,

Jérémy