System freeze/crash during data analysis

In my lab we serially process fairly large digital (~3.5 GB) signals which are loaded from disk. All this processing is wrapped together in a gui-driven .m file. We've found that this code normally runs fine, but sometimes crashes windows 7 and linux machines, and the crash is pretty severe -- the system locks up entirely or just reboots. One 'solution' was to run the code in safe mode on windows, but there are problems with that. Any suggestions? We're running R2011b 64b matlab on both systems.

-Davis

[Daniel Shub]

Are you using 64 bit MATLAB? How much RAM do your systems have? Do you know if you are using so much memory that you start using virtual (disk based) memory? How frequently do teh crashes happen? Do you know where in the code?

[Walter Roberson]

Overheating ?

Also, do you have ECC memory, or parity, or no error detection/correction ?