How to denoise this image?

I have two image

1. Noisy Image

2. Targetted Image

I am totally confused and tried different filters like Weiner, median, bilat, etc but confused about how to proceed for this to denoise this image?

figure;
subplot(2,2,1);
imshow(noisy);

af=fftshift(fft2(noisy));
subplot(2,2,2);
imshow(mat2gray(log(1+abs(af))));

subplot(2,2,3);
imshow(real_img);

af2=fftshift(fft2(real_img));
subplot(2,2,4);
imshow(mat2gray(log(1+abs(af2))));