Dynamic contrast agent in MRI

Hi everyone.

I just wondering if someone has worked with perfussion MRI images. I have a DCE experiment in kidneys and I would like to work with matlab to obtain the parameters of the model (one compartment, two compartment...), I want to work with Simbiology

Thanks a lot.

Regards

Answer 1

[William Rose]

@MARINA,

[Edit: fix spelling.]

I have worked with MRI images, but not with perfusion images. I have also worked with fitting compartmental models. But not with Simbiology.

See Zollner et al, 2021 for a good description of analysis procedures. Zollner et al assume the user has certain non-Matlab software packages. Even if you don't have those packages, Zollner's chapter is useful.

To avoid re-inventing the wheel, check out the Matlab file exchange submissions for MRI imaging and for perfusion model fitting. For example, MP3 Medical Imaging Toolbox; 4D medical image de-noising; 4D data exploration; View4D; and two packages by excellent authors who have helped many of us on Matlab Answers: Image Manipulation Toolbox by @DGM and Image Segmentation Tutorial by @Image Analyst.

References:

Dynamic Contrast Enhancement (DCE) MRI–Derived Renal Perfusion and Filtration: Basic Concepts, Pertersen et al., 2021.

Dynamic Contrast Enhanced (DCE) MRI-Derived Renal Perfusion and Filtration: Experimental Protocol. Irrera et al., 2021.

Analysis Protocol for Dynamic Contrast Enhanced (DCE) MRI of Renal Perfusion and Filtration. Zöllner et al., 2021.

Good luck with your research.

[MARINA]

Thanks a lot. I am working in preclinical MRI (mice and rats).

Anyway, many thanks for all the information you have answered me . I would check everything you told me.

I am new with matlab and I wanted to learn about this.

Regards

[William Rose]

@MARINA, you're welcome.