Simbiology Model Analyzer: input error for CMAX and Partial AUC

Hi I am using SimBiology Model Analyzer to run a non-compartmental analysis. The program runs fine with the default parameters.

However, if I try to specify a CMAX time range or partial AUC range by typing, for example, [1 24], the following error messages occur: "Invalid input argument of type 'cell'. Input must be a structure or a Java or COM object."

Can someone offer help or suggestions? Data is attached. Thank you in advance.

For reference, I used the exact syntax as minute 3:55 of this instructional video from Matlab (https://www.mathworks.com/videos/simbiology-tutorial-importing-data-and-noncompartmental-analysis-1600088547318.html)

Answer 1

[Arthur Goldsipe]

Hi,

This is a bug. The bug is triggered if you try to calculate partial areas and some of the subjects don't have enough measurements.

In your case, subjects 1 and 7 have no concentration measurements. If you don't specify a time for partial AUC, you will see that the NCA parameters for these two subjects are all listed as NaN.

I think the easiest way to work around this bug would be to exlude the data for subjects 1 and 7. One way to do that is as follows:

• Import the data into the SimBiology Model Analyzer app.
• Right-click on the datasheet table and select "Exclude Data by Expression".
• In the editor, add exclusions for Subject==1 and Subject==1.

I'm attaching a R2024b SimBiology project that illustrates this.

[Fan]

Thank you!