Discrete Transfer function different "fixed Word" lengths while HDL code generation

Hi, I would like to set differnet word lengths while doing HDL code generation,

Can I set a Discrete TF block to the different word lengths at below these three locations.

Input port , = 10bit

Inside blocks =16 bit, like accumulator , Multiplier , gain etc ,

Output port ,= 10 bit or 12bit

(How much does it affect the output resolution)

OR all must be same word length?

Thanks,