I am interested in using simbiology to simulate ~96 to ~144 different chemical reactions related to the TCA cycle. They would all be solved simultaneously. I just tried out the simbiology toolbox. It seems very powerful, but I just did some very basic rxn kinetics. Does anyone have experience with simbiology? Could I expect it to handle this many equations simultaneously? I make the approximation that most reactions are first order, though some of them will be "ping-pong". Would such a simulation run faster if I just wrote it myself in matlab? Does simbiology put extra overhead on the processes? I would probably want to run the simulation for 100 to 500 different time points.