How can Simbiology dosing be administered continuously instead of discretely?
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MathWorks Support Team
le 12 Juil 2017
Modifié(e) : MathWorks Support Team
le 18 Avr 2024
How can dosing be administered continuously instead of discretely?
Here is what I am currently trying:
-Start the Simbiology App
-Add a Linear {Clearance, Volume} Infusion Model
-Add a "schedule dose" to the model under "Dose_Central"
-Double click green table next to 'dose_1'
-Click "Editor..." button
I am unsure of how to specify the dosage so that it is continuous instead of providing a discrete amount at each time. I have looked through some documentation on dosing but was unclear if there was an easy way to change the 'rate' to accomplish this.
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MathWorks Support Team
le 18 Avr 2024
Modifié(e) : MathWorks Support Team
le 18 Avr 2024
There are two ways to implement continuous dosing:
1) Use a repeat or scheduled dose with just one dose starting at t=0. You can set the 'rate' parameter to the rate you need and set the 'amount' parameter to a large number. This way, the total amount will never be reached and the dose is given continuously. Your 'amount' should be larger than 'rate*(duration of simulation)'
2) Instead of a dose object you can introduce a reaction “null -> species” reaction with a rate parameter k and mass action kinetics. This describes a continuous synthesis or dosing of “species”.
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