Non blocking while loop in appdesigner?

I want to create a GUI with a continously running while loop as main processing part, while using callbacks and the matlab command prompt

What I want to do, is Start the GUI, do some initialisation and than start a while loop which processes data as quick as possible. (DAQ is done with a timer).

While in this "MainLoop", I want to be able to react to callbacks and most importantly, I want to be able to continue to use the matlab main window.

While I can react to callbacks, Matlab wont process any inputs to the command line while inside the main loop.

I tried 3 different methods to start the main loop, but none works.

The only thing that works is deleting the while loop as the execution function of a periodic timer, however, this is too slow (and unflexible) for the quite short MainLoop.

Is there a way to keep the command prompt working and not using timers?

MainLoop:

function MainLoop(app)           
            while ~app.StopFlag             
                    app.ProcessingIteration = app.ProcessingIteration +1;                    
                    disp(['Iter: ' num2str(app.ProcessingIteration)]);
                    pause(0.1)
                    drawnow limitrate;
            end
        end

Method 1: Direct Start from startupFcn

        function startupFcn(app)
            app.MainLoop(); 
        end

Method 2: Starting via One-Shot Timer

function startupFcn(app)
    app.Timer = timer('ExecutionMode', 'singleShot','Name','MainLoop','StartDelay',2);
    app.Timer.TimerFcn = @(~,~)app.MainLoop();
end

Method 3: Starting via Button Press

function ButtonPushed(app, event)
    app.MainLoop();
end