n Transit compartment in 2-compartment PK model in Simbiology

Greetings,

In looking at the solution provided for the transit compartments simbiology file, I attempted to edit to make it a 2-cpt model with transit compartments.

Would you be able to help me modify this code located in a simbiology file at the bottom of this post to be a 2-compartment model with a transit compartment.

https://www.mathworks.com/matlabcentral/answers/457059-n-transit-compartment-single-distribution-compartment-pk-absorption-model-in-simbiology

I would like to do a model fit and then simulate the transit (three transit compartments) with a 2-compartment pk model with first order absorption.

I would want to fit the following paramters: Vc, Vp, CL, Q, Mtt, N (for # of transit compartments). The model here is for a 1 compartment model:

https://www.mathworks.com/matlabcentral/answers/uploaded_files/216437/nTransit_1Comp_ver3.zip

Thanks for any help with this.

Andy

[Arthur Goldsipe]

I'm sorry, but I don't understand your question well enough to help. You said you want a 2-compartment model, and 3 transit compartments. But then later you say that you want to estimate N (the number of transit compartments). What is the difference between the various compartments in your model? Can you sketch out what you want to model in more detail? If you can tell us mathematically what you want to do, I am hopeful we would be able to help you implement the model in SimBiology.

[Andy]

Here is a visual of the pk transit compartment model I was looking to simulate in simbiology:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351003/figure/cts12423-fig-0001/

Answer 1

[Jeremy Huard]

Hi Andy,

I have attached a SimBiology implementation of a two compartment model with transit compartments.

I hope this helps.

Best regards,

Jérémy

[Andy]

Good morning Jérémy,

That is fantastic and this works well. One thing is that when I attempt to do multiple doses, the output graph still shows a single dose. I was looking to check the steady-state pharmacokinetic parameters.

This model does work well and I am able to have a better view on how to customize this in Simbiology.

Best regards,

Andy