- Set "body weight" column as a dose column - dose2 if you already have an actual dose in your dataset.
- Create a new species to represent body weight since only species can be dosed in SimBiology. Let's assume you call this species BW.
- Set the value of the parameter that represents bodyweight in the model using a repeated assignment rule bodyweight = BW and calculate AC with another repeated assignment rule as AC = BC*bodyweight.Note that it's important to use repeated assignment rules intead of an initial assingment rule. Since initial assingmentments are evaluated before dosing, using initial assigmnets can lead to problems.
- In fit data task/program, map the "body weight" data column with BW.
How to do model fitting in simbiology
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Dear Simbiology community,
I got 1 problem when I tried to fit data in simbiology. I am doing a population model fitting.
I have 1 column called "body weight" in my dataset. In that case, one parameter called 'AC' in my model could have different values for different IDs (subjects) (AC=BC*body weight). How could I let simbiology know this parameter 'AC' could change for different IDs? Should I revise my dataset or add parameters in my model?
I appreciate if someone could provide answers in detail. Thanks in advance!
Fulden Buyukozturk on 18 Feb 2020
Edited: Fulden Buyukozturk on 18 Feb 2020
You can "dose" Body Weight to achieve this:
Please let me know if this helps.