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As part of MATLAB Central’s 20 year anniversary celebration, we created the MATLAB Mini Hack . The contest starts today on Oct. 4th!

What to do?

Generate an interesting image using up to 280 characters of MATLAB code.

Who can play?

Participants across all skill levels are welcome. Create original entries of your own code, remix others’ entries and make them your own, or simply vote on ENTRIES you love!

How to win prizes?

Those at the top of the leaderboard at the end of the contest will win up to $300 Amazon gift cards, 5 customized T-shirts, or special badges. Visit the prizes section on the contest page for more information.

To add more fun, we will award RANDOM PRIZES that every participant has a chance to win.

• Each week, we will pick 5 players who participate in both the Treasure Hunt and MATLAB Mini Hack .
• Each week, we will have different surprise giveaways.

Important Notes

• The first week (Oct. 4th, 2021 ~ Oct. 10th 2021) is for creating entries only. Voting starts on Week 2.
• Make sure you follow the contests (click the ‘follow the contests’ button on the top) to get notified when prizes are awarded and of other important announcements. We hope you are the winner!

Join our celebration of the 20th anniversary of MATLAB Central community! You are invited to enter 2 contests - A Treasure Hunt and a MATLAB Mini Hack - to have fun and win prizes.

How to Play

• In the Treasure Hunt, complete 10 fun tasks to explore the ‘treasures’ in the community.
• In the MATLAB Mini Hack, use up to 280 characters of MATLAB code to generate an interesting image. Simply vote for the entries that you like or share your own entries to gain votes.

Prizes

You will have opportunities to win compelling prizes, including special edition T-shirts, customized T-shirts, Amazon gift cards, and virtual badges. Your participation will also bump up our charity donations.

Ready to participate?

Visit the community contests space and choose the contest you’d like to enter. Note that:

• You need a MathWorks account to participate. If you don’t have a MathWorks account, you can create one at MathWorks sign in .
• Make sure you follow the contests (click the ‘follow the contests’ button on the top) to get notified for prize information and important announcements.

For the full contest rules, prizes, and terms, see details here .

We hope you enjoy the contests and win big prizes. NOW, LET THE CELEBRATION BEGIN!

Hello

I would like to pulse an input species. I read in the forums that repeated assignments can be used for this, but I am not exactly sure how to implement this. This is the MATLAB code that resembles what I would like the input pattern to be:

t = 0:1/1e3:60;
d = [10:2:30]';
x = @rectpuls;
y = pulstran(t,d,x);

plot(t,y)
hold off
xlabel('Time (s)')
ylabel('Waveform')

Thanks for any help! Aaron

Hello, We would like to share one of our QSP models with non-modeler colleagues for them to play with. Is there a simple way to generate a standalone app from a SimBiology model, with sliders allowing the user to change various parameter values?

Thank you,

Abed

Happy New Year, everyone! We hope you enjoyed the Cody contest in 2020, learned new MATLAB skills, and made a friend or two. While the 2020 contest has concluded, the fun and learning never end.

Please take the 1-minute survey to talk about your experience (only 2 required questions). Our goal is to make future contests better and more appealing to you, so your feedback is critical to us.

Thank you in advance and hope to see you again in the 2021 contest.

Hello, Does the 'sbiofit' function have functionality implemented for likelihood=based handling of BLoQ censored data, similar to functionality in NONMEM and other softwares? If not, are there plans to implement this?

Thanks,

Abed

Hello,

I recently downloaded the GlobalSensitivityAnalysisApp. I am trying to perform a GSA using a simbiology model. I try running the App, but I get the error "No Sobol Indices Available to Plot. Configure the Sobol section and click the Compute button." I'm not sure if there is a step I'm overlooking. I'm following the instructional video for this app on the Matlab website, and I'm not sure what Configure the Sobol section is referring to. Any guidance would be greatly appreciated.

We are excited to announce that Cody Contest 2020 starts today! Again, the rule is simple - solve any problem and rate its difficulty. If you have any question, please visit our FAQs page first. Want to know your ranking? Check out the contest leaderboard .

Happy problem-solving! We hope you are a winner.

Below are some FAQs for the Cody contest 2020. If you have any additional questions, ask your questions by replying to this post. We will keep updating the FAQs.

Q1: If I rate a problem I solved before the contest, will I still get a raffle ticket?

A: Yes. You can rate any problem you have solved, whether it was before or during the contest period.

Q2: When will I receive the contest badges that I've earned?

A: All badges will be awarded after the contest ends.

Q3: How do I know if I’m the raffle winner?

A: If you are a winner, we will contact you to get your name and mailing address. You can find the list of winners on the Cody contest page .

Q4: When will I receive my T-shirt or hat?

A: You will typically receive your prize within a few weeks. It might take longer for international shipping.

Q5: I'm new to Cody. If I have some questions about using Cody, how can I get help?

A: You can ask your question by replying this post. Other community users might help you and we will also monitor the threads. You might also find answers here .

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A: Use Web Site Feedback . Select "MATLAB Central" from the category list.

Q8: Why can't I rate a problem?

A: To rate a problem, you must solve that problem first and have at least 50 total points.

How can I add the value of the error for each estimated parameter?

Hi, all

Recently I read the book "Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry" and find this state,"Since the unbound concentrations in plasma and blood are expected to be the same, fub , fup , and R are related as follows: R=Cb/Cp=(Cub·fup)/(Cup·fub) and R=fup/fub". I don't know whether it is reasonable to generally assume unbound concentrations in plasma and blood to be the same since components in whole blood and plasma are not the same. Is it common to see this equality in real situation?

Thanks for comment.

Hello,

We're working with a vendor to expand one of our current models that's written in SimBiology, but that vendor doesn't have a license to SimBiology. It would be nice if there existed a "Simbiology Viewer" which can be downloaded as a free Matlab package, and which would allow one to view but not edit SimBiology models. Are there any plans for something like this in the future? Something like this would make it much easier to share our models with people who don't have a license to SimBiology.

On a similar note, does anyone have any advice on the best ways to share SimBiology models currently? I noticed there's some functionality to export the tables of reactions, parameters, species, etc., and there's also some functionality to export the model into SBML.

Thank you,

Abed

Hi, all friends,

I want to record the fraction of drug absorbed in each intestinal segment, so I define a set of parameters with rate rule like: AbFraction_Colon= ((PeffColon*2/organismRadiusColon+paracellularAbsorption*organismFluxMucosaSerosa/Colon)*Colon.DrugDissolved)*Colon/InitialDose The attached figure shows the simulation result that overall PK profile (purple) seems OK, but I don't know why the absorption fraction line (red) starts from value of 1. Does anyone know the cause?

By the way, I am using model modified from "generic PBPK model"

Thanks for comment.

Hi, all friends

I am dealing with a confusing NCA result. As this result shows, AUC_infinity=0.8537 (μg*h/mL), DM=1 (mg). CL should be equal to DM/AUC_infinity but why is the calculated result 2.4491? There is no dimension along with value so I do not know if I ignore anything.

Does any one can handle with this situation? Thanks very much. I also post my used data (i.v.).

Hi, all friends

If I define a parameter, like solubility with dimension of milligram/milliliter and I want to refer it in an reaction equation in dimension of millimole/liter, suppose I have define its molecularweight, could I input this parameter directly in equation with specified dimension?

Question: How to load a host of variants created through scripts to a sbproj file so that we can simulate and visualize them through the simbiology GUI.

Description : In a typical QSP workflow, we generate virtual patients by perturbing a set of parameters. These virtual patients are generated as variants by using "addvariant".

We end up with an array of variants saved as "variants.mat". This mat contains the list of ~3000 variants.

These variants are now to be simulated with different dose objects. This could be done with scripts but it would be ideal if we import these variants into the sbproj file and simulate via simbiology GUI for both purpose of troubleshooting and dosing.

Is there a way to do this?

Hi, all friends

I am working on building a oral model with "Generic SimBiology PBPK model" and meet some problems about intestinal transit rate. Take duodenum as example, the transit rate is defined as " (kTransportSmallIntestine*organismLengthDuodenum/organismLengthSmallInstestine)*Duodenum.DrugDissolved". I think assuming duodenum transit time is equal to SmallIntestineTransittime*organismLengthDuodenum/organismLengthSmallInstestine, the transit rate constant is the inverse of that,which result in kTransportSmallIntestine*organismLengthSmallInstestine/organismLengthDuodenum, contradicting with the equation in model. Am I wrong?

Besides that, the kTransportSmallIntestine_is defined as _0.693/organismMeanResidenceSmallIntestine in model. Isn't the mean residence time determining the time at which about 63.2% of initial amount having passed through the compartment and inverse of mean residence time determining the transit rate? Why does organismMeanResidenceSmallIntestine correlate with 0.693 which is often seen in half-life associated expression?

Thanks for any comment.