Open Source Patient Simulator

Open Source Patient Simulator for Design and Evaluation of Computer Based Drug Dosing Control for Anesthetic and Hemodynamic Variables

The patient simulator platform is designed through an interdisciplinary combination of medical, clinical
practice and systems engineering expertise gathered in the last decades by our team. The result is an
open source patient simulator in Matlab/Simulink from Mathworks(R). Simulator features include complex
synergic and antagonistic interaction aspects between general anesthesia and hemodynamic stabilization
variables. The anesthetic system includes the hypnosis, analgesia and neuromuscular blockade states, while
the hemodynamic system includes the cardiac output and mean arterial pressure. Nociceptor stimulation
is also described and acts as a disturbance together with predefined surgery profiles from a translation
into signal form of most commonly encountered events in clinical practice.