U =
The expression is apparently incomplete.
Working with what is provided —
syms e e1 e2 h1 h2 h3 A B
U = 108*A^2*e^7*e1^3*e2^7*h2^4 + 153*A^2*e^7*e1^5*e2^7*h2^2 + 108*A^2*e^7*e1^7*e2^3*h3^4 + 153*A^2*e^7*e1^7*e2^5*h3^2 +...
24*B^2*e^3*e1^7*e2^7*h1^4 + 95*B^2*e^5*e1^7*e2^7*h1^2 + 24*B^2*e^7*e1^3*e2^7*h2^4 + 95*B^2*e^7*e1^5*e2^7*h2^2 + ...
24*B^2*e^7*e1^7*e2^3*h3^4 + 95*B^2*e^7*e1^7*e2^5*h3^2 + 9*A^2*e^2*e1^7*h1^5*h3^7 + 9*A^2*e^2*e2^7*h1^5*h2^7 +...
9*A^2*e1^2*e2^7*h1^7*h2^5 + 9*A^2*e^7*e1^2*h2^5*h3^7 + 9*A^2*e^7*e2^2*h2^7*h3^5 + 9*A^2*e1^7*e2^2*h1^7*h3^5 -...
41*B^2*e^2*e1^7*h1^5*h3^7 - 41*B^2*e^2*e2^7*h1^5*h2^7 - 12*B^2*e^4*e1^7*h1^3*h3^7 - 12*B^2*e^4*e2^7*h1^3*h2^7 -....
41*B^2*e1^2*e2^7*h1^7*h2^5 - 12*B^2*e1^4*e2^7*h1^7*h2^3 - 41*B^2*e^7*e1^2*h2^5*h3^7 - 12*B^2*e^7*e1^4*h2^3*h3^7 - ...
41*B^2*e^7*e2^2*h2^7*h3^5 - 12*B^2*e^7*e2^4*h2^7*h3^3 - 41*B^2*e1^7*e2^2*h1^7*h3^5 - 12*B^2*e1^7*e2^4*h1^7*h3^3 -...
504*A^2*e^3*h1^4*h2^7*h3^7 + 9*A^2*e^5*h1^2*h2^7*h3^7 - 504*A^2*e1^3*h1^7*h2^4*h3^7 + 9*A^2*e1^5*h1^7*h2^2*h3^7 -...
504*A^2*e2^3*h1^7*h2^7*h3^4 + 9*A^2*e2^5*h1^7*h2^7*h3^2 + 2860*B^2*e^3*h1^4*h2^7*h3^7 - 377*B^2*e^5*h1^2*h2^7*h3^7 +...
2860*B^2*e1^3*h1^7*h2^4*h3^7 - 377*B^2*e1^5*h1^7*h2^2*h3^7 + 2860*B^2*e2^3*h1^7*h2^7*h3^4 - 377*B^2*e2^5*h1^7*h2^7*h3^2 +...
162*A*B*e^7*e1^7*e2^7 - 6*A*B*e^7*h2^7*h3^7 - 6*A*B*e1^7*h1^7*h3^7 - 6*A*B*e2^7*h1^7*h2^7 + 1944*A^2*e*h1^6*h2^7*h3^7 + ...
1944*A^2*e1*h1^7*h2^6*h3^7 + 1944*A^2*e2*h1^7*h2^7*h3^6 - 5400*B^2*e*h1^6*h2^7*h3^7 - 5400*B^2*e1*h1^7*h2^6*h3^7 -...
245*B^2*e^6*e1^7*e2^4*h1*h3^3 + 147*B^2*e^7*e1*e2^3*h2^6*h3^4 + 48*B^2*e^7*e1*e2^5*h2^6*h3^2 - 60*B^2*e^7*e1^2*e2^6*h2^5*h3 + ...
147*B^2*e^7*e1^3*e2*h2^4*h3^6 - 245*B^2*e^7*e1^4*e2^6*h2^3*h3 + 48*B^2*e^7*e1^5*e2*h2^2*h3^6 - 60*B^2*e^7*e1^6*e2^2*h2*h3^5
U = simplify(U, 1000) % It May Not Simplify Further
Ukids = children(U) % Return Sub-Expressions
% for k1 = 1:numel(Ukids) % Symbolic Version Of The 'unique' Function
% Test = Ukids(k);
% for k2 = k1:numel(Ukids)
% Check(k1) = isAlways(Test == Ukids{k2});
% end
% end
% Check
Using the children function, it returns 57 apparently unique substrings (I did not check all of them with the commented-out loops, since the unique function does not work with symbolic objects).
So that may be the best you can do. As to whether they can be replaced by specific symbolic variables or symbolic fucntions, perhaps yes. I defer to you for that experiment, using the subs function.
.